ORGANIZERS

CHAIRPERSON: JOHN W ERDMAN JR

VICE - CHAIR: HELMUT SIES

PAST CHAIRS: JAMES A OLSON, NORMAN I KRINSKY

October 13, 1997

Tentative Program

3rd Gordon Research Conference on Carotenoids

SUNDAY, JAN 25

Registration (2 - 6 pm; 7 - 9 pm)

Dinner (6 - 7 pm)

WELCOME: John Erdman (7:00 pm)

Session 1 Chemistry, characterization, and manufacturing (7:30 - 10:00)

Discussion leader: Jim Clark - Henkel Fine Chemicals, LaGrange, IL.

Speakers:

1 Hanspeter Pfander - University of Berne, Berne, Switzerland

Chemistry

2 Ami Ben Amotz - Israel Oceanographic & Limnological Res Ltd,

Haifa

Industrial manufacturing of carotenoids in algae

MONDAY, JAN 26th

Breakfast (7:30 - 8:30 am)

Poster viewing - Chair: Helmut Sies, (Poster Group I) (7:30 - 8:30 am)

Announcements (8:30 - 9:00 am): John Erdman/Helmut Sies

Session 2 Absorption, transport, tissue distribution, and metabolism

of carotenoids (9 am - noon)

Discussion Leader: Robert Russell - Human Nutrition Research Center

on Aging at Tufts University, Boston, MA.

Speakers:

3 Henk van den Berg - TNO Nutrition and Food Res. Inst., Utrecht,

The Netherlands

Absorption of xanthophylls, interaction with ß-carotene

4 John Landrum - Florida International University, Miami FL

Action and metabolism of xanthophylls in the human macula

5 Xiang-Dong Wang - USDA Human Nutrition Research Center on

Aging at Tufts University, Boston, MA

Metabolism of ß-carotene into retinoic acid and other oxidative metabolites

6 H. Bachmann - Hoffmann-La Roche Ltd, Basel, Switzerland

The physiology of carotenoids

Conference photo (TBA)

Lunch (12:30 - 1:30 pm)

Poster viewing (Poster Group I) (5 - 6 pm)

Dinner (6 - 7 pm)

Session 3 Carotenoids in non-mammalian and non-plant systems

(7:30-9:30 pm)

Discussion Leader: Synnove Liaaen-Jensen - Norwegian Inst. Tech.,

Trondheim, Norway

Speakers:

7 George Britton - University of Liverpool, Liverpool, UK

Carotenoid-protein interaction in maritime organisms

8 May Berenbaum - University of Illinois, Urbana, IL

Metabolic roles of carotenoids in insects

TUESDAY, JAN 27

Breakfast (7:30 - 8:30 am)

Poster viewing (Poster Group I) (7:30 - 9 am)

Session 4 Photosynthetic and model systems: Structure and

photochemistry (9:00 - noon)

Discussion Leader: Harry Frank - University of Connecticut, Storrs, CT

Speakers:

9 Roger Hiller - Australia

Structure and reconstitution of peridinin-chlorophyll a proteins (PCPs)

10 Wieslaw Gruszecki - Marie Curie-Sklodowska University,

Lublin, Poland

Carotenoid actions in membranes

11 Ana Moore - Arizona State University, Tempe, AZ

Proposed mechanisms of action of carotenoids in plants explored in

artificial systems

12 Richard Cogdell - University of Glasgow, Glasgow, UK

Carotenoids as light harvesting pigments

Lunch (12:30 - 1:30 pm)

Poster viewing (Poster Group I) (5 - 6 pm)

Dinner (6 - 7 pm)

Session 5

Poster Award 5 minute presentations from Poster Group I (7:30 - 8:00)

Carotenoid biosynthesis and the xanthophyll cycle (8:00 - 9:45 pm)

Discussion Leader: Harry Yamamoto - University of Hawaii, Honolulu, HI

Speakers:

13 Yossi Hirschberg - The Hebrew University of Jerusalem, Israel

Carotenoid biosynthesis: lessons from gene cloning

14 Andrew Young - John Moores University, Liverpool, UK

The xanthophyll cycle

WEDNESDAY, JAN 28

Breakfast (7:30 - 8:30 am)

Poster viewing - Chair, Norman Krinsky (Poster Group II) (7:30 - 9 am)

Session 6 Biological effects of carotenoids (9 - noon)

Discussion Leader: John Bertram - University of Hawaii, Honolulu, HI

Speakers:

15 Wilhelm Stahl - Heinrich Heine University, Dusseldorf, Germany

Possible biological targets of carotenoids, carotenoid metabolites, and

oxidation products

16 Yoav Sharoni - Beer-Sheva, Israel

Mechanisms for carotenoid inhibition of cancer cell proliferation

17 Pierre Astorg - Dijon, France

Carotenoids as inducers or inhibitors of cytochrome P-450 enzymes

18 Carmen Socaciu - University of Agricultural Sciences and

Veterinary Medicine, Romania

Carotenoid actions on cellular activity by different signal molecules

19 Discussant

Yoshihiro Shidoji - Institute of Applied Biochemistry, Gifu, Japan

Lunch (12:30 - 1:30 pm)

Poster viewing (Poster Group II) (5 - 6)

Dinner (6 -7 pm)

Session 7 Anti- and Pro-oxidation (7:30 - 9:30)

Discussion Leader: George Truscott - Keele University, England, UK

Speakers:

20 Daniel Liebler - University of Arizona, Tucson, AZ

Prooxidant and antioxidant interactions of ß-carotene with cigarette smoke

21 Junji Terao - National Food Research Institute, Japan

Role of carotenoids in dietary antioxidants from plant foods

THURSDAY, JAN 29

Breakfast (7:30 - 8:30 am)

Poster viewing (Poster Session II) (7:30 - 9)

Session 8 Carotenoids and chronic disease risk

Discussion leader: Phyllis Bowen - University of Illinois, Chicago, IL.

Speakers:

22 Susan Mayne - Yale University, New Haven, CT

Sorting it all out: Antioxidant protection or prooxidant stimulation from carotenoid supplements

23 Steven Clinton - Dana Farber Cancer Inst., Boston, MA.

Lycopene and prostate cancer

24 Julie Buring - Brigham and Women's Hospital, Harvard University,

Boston, MA.

Carotenoids and CVD: the epidemiologic evidence

25 Simin Meydani - Human Nutrition Research Center on Aging

and Tufts University, Boston MA.

Carotenoids and immunity

Lunch (12:30 - 1:30 pm)

Business Meeting (1:30 - 2:30 pm)

Conference Dinner (6 - 7:30 pm)

Session 9

Poster Award 5 minute presentations from Poster Group II (7:30 - 8:00)

Keynote Lecture (8:00 - 9:30)

Discussion leader: John Erdman - University of Illinois, Urbana, IL

Speakers:

25 James Olson - Iowa State University, Ames, IA

Carotenoids through the millennium: Sights for sore eyes

Closing Remarks: John Erdman and Helmut Sies

NOTES: In each of the 180 minute morning session, the expected time distribution is: Discussion leader's overview, 15 minutes: each speaker, 20 minutes with 65 minutes of total general discussion ( broken up to provide some time following each presentation and also following the entire session). For evening sessions the discussion leader again gets 15 minutes and each speaker 20 with a total of 25 minutes of discussion periods.

Four poster winners will be selected from Group I and four from Group II . Authors will be asked to orally present a 5 minute summary of their posters using up to 4 slides or overheads.